|
KMID : 1240020180220000156
|
|
International Neurourology Journal
2018 Volume.22 No. 0 p.156 ~ p.164
|
|
|
PI3K-Akt-Wnt Pathway Is Implicated in Exercise-Induced Improvement of Short-term Memory in Cerebral Palsy Rats
|
|
Cho Jung-Wan
Jung Sun-Young
Kim Dae-Young
Chung Yong-Rak
Choi Hyun-Hee
Jeon Jung-Won
Han Jin-Hee
|
|
|
Abstract
|
|
|
Purpose: Maternal lipopolysaccharide (LPS) injection induces neurodevelopmental disorders, such as cerebral palsy. Exercise activates phosphatidylinositol 3-kinase (PI3K)-protein kinase B (Akt) signaling pathway that enhances neurogenesis. Wnt ligands are also implicated in the hippocampal neurogenesis and synaptic plasticity. Glycogen synthase kinase-3β (GSK-3β) is a downstream molecule of Akt, and GSK-3β is known to modulate hippocampal neurogenesis negatively.
Methods: Cerebral palsy was made by maternal LPS-injection. On the 5 weeks after birth, treadmill running was applied to the rat pups of the exercise groups, for 30 minutes, 5 times a week during 6 weeks.
Results: Treadmill running alleviated short-term memory impairments of the cerebral palsy rat pups. Hippocampal cell proliferation was increased and hippocampal apoptosis was suppressed by treadmill running in the cerebral palsy rat pups. Hippocampal phosphorylated-PI3K/PI3K ratio, phosphorylated-Akt/Akt ratio, and Wnt expression were enhanced by treadmill running in the cerebral palsy rat pups. In contrast, hippocampal phosphorylated-GSK-3β/GSK-3β ratio and β-catenin expression were suppressed by treadmill running in the cerebral palsy rat pups.
Conclusions: The results of this study showed that short-term memory improvement due to treadmill running in cerebral palsy occurs via activation of the PI3K-Akt-Wnt pathway.
|
|
|
KEYWORD
|
|
|
Cerebral palsy, Short-term memory, Phosphatidylinositol 3-kinase, Protein kinase B, Glycogen synthase kinase-3β
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
 
|